We reviewed the effect of poor life conditions of pregnant mother living in developing countries on DNA methylation of their neonates and there making susceptible the newborn himself and also his/her upcoming generation susceptible to chronic disease. we searched PubMed, google scholar, Web of Science, Crossref for the original research conducted in developing countries to assess the effect of  nutrient deficient diet, stress and pollution on neonatal DNA methylation. however due to limited research conducted in developing countries we were not able to do meta analyses but we reviewed the results of available knowledge dietary habits in most of developing countries and shortage of food causes the deficiency of essential nutrient and therefore, causes aberrant DNA methylation or the methylation of the most important genes, but more research is needed. To study the effect of pollutants, and stress there were not sufficient studies conducted in developing countries so we included the studies conducted in upper middle income countries or data of high income countries, then compared with the possible effect in developing countries, definitely the results may 
be sever in developing countries.